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Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs

Administration of selective serotonin reuptake inhibitors (SSRIs) is associated with a reduced cancer risk and shows significant anti-tumor effects across multiple tumor types, suggesting the potential for repurposing SSRIs in cancer therapy. Nonetheless, the specific molecular target and mechanism...

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Principais autores: Fangyuan Dong, Shan Zhang, Kaiyuan Song, Luju Jiang, Li-Peng Hu, Qing Li, Xue-Li Zhang, Jun Li, Mingxuan Feng, Zhi-Wei Cai, Hong-Fei Yao, Rong-Kun Li, Hui Li, Jie Chen, Xiaona Hu, Jiaofeng Wang, Chongyi Jiang, Helen He Zhu, Cun Wang, Lin-Tai Da, Zhi-Gang Zhang, Zhijun Bao, Xu Wang, Shu-Heng Jiang
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications Ltd 2026-02-01
Series:eLife
Assuntos:
drug repurposing
drug discovery
SLC6A4
SERT
5-HT
Acceso en liña:https://elifesciences.org/articles/103016
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