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IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infection

Dynamic regulation of cellular metabolism is important for maintaining homeostasis and can directly influence immune cell function and differentiation, including NK cell responses. Persistent HIV-1 infection leads to a state of chronic immune activation, NK cell subset redistribution, and progressiv...

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Autori principali: Elia Moreno-Cubero, Aljawharah Alrubayyi, Stefan Balint, Ane Ogbe, Upkar S. Gill, Rebecca Matthews, Sabine Kinloch, Fiona Burns, Sarah L. Rowland-Jones, Persephone Borrow, Anna Schurich, Michael Dustin, Dimitra Peppa
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical investigation 2024-02-01
Serie:JCI Insight
Soggetti:
AIDS/HIV
Immunology
Accesso online:https://doi.org/10.1172/jci.insight.173099
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