Clinical Risk Factors for High‐Dose Methotrexate‐Induced Oral Mucositis Following Individualized Dosing

ABSTRACT Background Oral mucositis affects about 20% of children undergoing high‐dose methotrexate (HDMTX) for acute lymphoblastic leukemia (ALL), despite existing management strategies. Personalized HDMTX dosing, adjusted by pharmacokinetics and leukemia risk, has reduced mucositis incidence, but v...

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Autori principali:	Zhongbo Hu, Andrea M. Escalera‐Joy, Emily Ashcraft, Rushil Acharya, Sima Jeha, Cheng Cheng, Ching‐Hon Pui
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2024-11-01
Serie:	Cancer Medicine
Soggetti:	acute kidney injury acute lymphoblastic leukemia delayed methotrexate clearance high‐dose methotrexate oral mucositis risk factors
Accesso online:	https://doi.org/10.1002/cam4.70351
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