Atropostatin: Design and Total Synthesis of an Atropisomeric Lactone–Atorvastatin Prodrug
Atorvastatins play an important role in the inhibition of HMG-CoA reductase, an enzyme present in the liver that takes part in the biosynthesis of cholesterol. In this article, we report the total synthesis of a lactone–atorvastatin prodrug with additional atropisomeric features. Conformational and...
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| Principais autores: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
MDPI AG
2023-04-01
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| Serija: | Molecules |
| Teme: | |
| Online dostop: | https://www.mdpi.com/1420-3049/28/7/3176 |
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