Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization

To test the hypothesis that increased Rap1a activity specifically in retinal pigment epithelial cells resists choroidal neovascularization (CNV), self-complementary adeno-associated virus 2 (scAAV2) with RPE65-promoter-driven GFP vectors were generated and introduced subretinally into Rap1b-deficien...

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Bibliografische Detailangaben

Hauptverfasser:	Haibo Wang, Xiaokun Han, Colin A Bretz, Silke Becker, Deeksha Gambhir, George W Smith, R Jude Samulski, Erika S Wittchen, Lawrence A Quilliam, Magdalena Chrzanowska-Wodnicka, M Elizabeth Hartnett
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2016-01-01
Schriftenreihe:	Molecular Therapy: Methods & Clinical Development
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2329050117300281
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