Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution

Summary: The representation of driver mutations in preleukemic hematopoietic stem cells (pHSCs) provides a window into the somatic evolution that precedes acute myeloid leukemia (AML). Here, we isolate pHSCs from the bone marrow of 16 patients diagnosed with AML and perform single-cell DNA sequencin...

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Bibliografski detalji

Glavni autori:	Gladys Poon, Aditi Vedi, Mathijs Sanders, Elisa Laurenti, Peter Valk, Jamie R. Blundell
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2025-02-01
Serija:	Cell Genomics
Teme:	acute myeloid leukemia cancer evolution clonal hematopoiesis somatic mutation pre-cancer early detection
Online pristup:	http://www.sciencedirect.com/science/article/pii/S2666979X24003732
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