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Real-world use of emapalumab in hemophagocytic lymphohistiocytosis: a scoping review of published evidence

BackgroundEmapalumab, an interferon-γ (interferon-gamma)–blocking monoclonal antibody, has emerged as a targeted therapy for refractory hemophagocytic lymphohistiocytosis (HLH). This scoping review summarizes real-world evidence of its clinical use across HLH subtypes.MethodsA comprehensive search o...

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Principais autores: Abdulrahman F. Al-Mashdali, Fatihelmgib Mohamed, Marwa Osman, Mujahid O. Abdelraof, Mona Al Rasheed, Hind Salama, Shehab F. Mohamed, Mohamed A. Yassin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-04-01
Serier:Frontiers in Pharmacology
Fag:
cytokine release syndrome
emapalumab
hemophagocytic lymphohistiocytosis
interferon-γ blockade
macrophageactivation syndrome
real-world evidence
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2026.1749084/full
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