Role of misfolding in rare enzymatic deficits and use of pharmacological chaperones as therapeutic approach

Cells have evolved sophisticated molecular control systems to maximize the efficiency of the folding process. However, any subtle alteration of the environment or the protein can lead to misfolding or affect the conformational plasticity of the native states. It has been widely demonstrated that mis...

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Opis bibliograficzny

Główni autorzy:	Gioena Pampalone, Silvia Grottelli, Leonardo Gatticchi, Emilia Maria Lombardi, Ilaria Bellezza, Barbara Cellini
Format:	Artigo
Język:	Inglês
Wydane:	IMR Press 2021-12-01
Seria:	Frontiers in Bioscience-Landmark
Hasła przedmiotowe:	misfolding parmacological chaperones gaucher disease phenylketonuria primary hyperoxaluria
Dostęp online:	https://www.imrpress.com/journal/FBL/26/12/10.52586/5056
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