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Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus

Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease in which the production of pathogenic autoantibodies depends on T follicular helper (TFH) cells. This study investigated the mechanisms by which the glycolysis inhibitor 2-deoxy-d-glucose (2DG) reduces the expansion of TFH cells an...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Seung Chul Choi, Yong Ge, Ahmed Elshikha, Yuk Pheel Park, Cenxiao Fang, Milind V. Joshi, Maria Montes de Oca Arena, Lauren Padilla, Yanan Zhu, William L. Clapp, Eric S. Sobel, Mansour Mohamadzadeh, Laurence Morel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2025-12-01
Schriftenreihe:Cell Reports
Schlagworte:
CP: immunology
CP: metabolism
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211124725013725
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