Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy

The nonphysiological nutrient levels found in traditional culture media have been shown to affect numerous aspects of cancer cell physiology, including how cells respond to certain therapeutic agents. Here, we comprehensively evaluated how physiological nutrient levels affect therapeutic response by...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Vipin Rawat, Patrick DeLear, Prarthana Prashanth, Mete Emir Ozgurses, Anteneh Tebeje, Philippa A. Burns, Kelly O. Conger, Christopher Solís, Yasir Hasnain, Anna Novikova, Jennifer E. Endress, Paloma González-Sánchez, Wentao Dong, Greg Stephanopoulos, Gina M. DeNicola, Isaac S. Harris, David Sept, Frank M. Mason, Jonathan L. Coloff
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Clinical investigation 2024-07-01
Σειρά:	JCI Insight
Θέματα:	Cell biology Oncology
Διαθέσιμο Online:	https://doi.org/10.1172/jci.insight.174329
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