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Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II

Abstract Background Lapachol is a natural naphthoquinone compound that possesses extensive biological activities. The aim of this study is to investigate the inhibitory effects of lapachol on rat C6 glioma both in vitro and in vivo, as well as the potential mechanisms. Methods The antitumor effect o...

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Principais autores: Huanli Xu, Qunying Chen, Hong Wang, Pingxiang Xu, Ru Yuan, Xiaorong Li, Lu Bai, Ming Xue
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2016-11-01
Series:Journal of Experimental & Clinical Cancer Research
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Acceso en liña:http://link.springer.com/article/10.1186/s13046-016-0455-3
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