Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation

ABSTRACT Intracellular killing of Streptococcus pneumoniae is complemented by induction of macrophage apoptosis. Here, we show that the toxin pneumolysin (PLY) contributes both to lysosomal/phagolysosomal membrane permeabilization (LMP), an upstream event programing susceptibility to apoptosis, and...

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Hlavní autoři:	Martin A. Bewley, Michael Naughton, Julie Preston, Andrea Mitchell, Ashleigh Holmes, Helen M. Marriott, Robert C. Read, Timothy J. Mitchell, Moira K. B. Whyte, David H. Dockrell
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2014-10-01
Edice:	mBio
On-line přístup:	https://journals.asm.org/doi/10.1128/mBio.01710-14
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