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Structural and functional constraints on spike activation and host protease utilization limit cell entry of SARS-CoV-2-related bat coronaviruses

ABSTRACT The persistent threat posed by SARS-CoV-2-related coronaviruses (SC2r-CoVs) in wildlife highlights the risk of zoonotic transmission. Cross-species infectivity is predominantly determined by spike (S) character and S-mediated cell entry. In this study, we systematically investigated BANAL-5...

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Principais autores: Qingqing Li, Xiao Cai, Xiaoning Li, Yibing Zhang, Ru Li, Zirui Kang, Didi Wan, Jiaxu Wang, Lili Li, Junxia Yang, Jianxiang Shi, Shuiling Jin, Xiangdong Sun, Ying Peng, Na Zang, Zhengkun Xie, Yushun Wan, Jian Shang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2025-08-01
Serier:Journal of Virology
Fag:
cross-species transmission
membrane fusion
cryo-EM structure
receptor binding
spike
SARS-CoV-2-related coronavirus
Online adgang:https://journals.asm.org/doi/10.1128/jvi.01007-25
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