The fibroblast epigenome underlies SS18::SSX-mediated transformation in synovial sarcoma

Abstract Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy that is characterised by a pathognomonic t(X;18)(p11.2;q11.2) translocation, which produces the fusion oncogene named SS18::SSX. Despite recent advancements in our understanding of synovial sarcoma biology, the cell-of-origin re...

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Principais autores:	Lesley A. Hill, R. Wilder Scott, Lauren A. Martin, Martin Arostegui, George Davenport, Marcos Vemon, Jakob Hofvander, Xue Qi Wang, Jinxiu Li, Torsten O. Nielsen, Kevin B. Jones, Martin Hirst, T. Michael Underhill
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-12-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-025-65850-5
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