The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

Abstract Glutamatergic excitotoxicity is hypothesised to underlie synaptic loss in schizophrenia pathogenesis, but it is unknown whether synaptic markers are related to glutamatergic function in vivo. Additionally, it has been proposed that N-acetyl aspartate (NAA) levels reflect neuronal integrity....

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Detalhes bibliográficos

Principais autores:	Ellis Chika Onwordi, Thomas Whitehurst, Ayla Mansur, Ben Statton, Alaine Berry, Marina Quinlan, Declan P. O’Regan, Maria Rogdaki, Tiago Reis Marques, Eugenii A. Rabiner, Roger N. Gunn, Anthony C. Vernon, Sridhar Natesan, Oliver D. Howes
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2021-07-01
coleção:	Translational Psychiatry
Acesso em linha:	https://doi.org/10.1038/s41398-021-01515-3
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