Improved Translational Relevance of In Vitro Fibrosis Models by Integrating IOX2-Mediated Hypoxia-Mimicking Pathways

<b>Background/Objectives</b>: Preclinical models of liver fibrosis only partially mimic human disease processes. Particularly, traditional transforming growth factor beta 1 (TGFβ1)-induced hepatic stellate cell (HSC) models lack relevant processes, including hypoxia-induced pathways. Here, the abili...

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Principais autores:	Manuel A. González Hernández, Jennifer Venhorst, Lars Verschuren, Karin Toet, Martien P. M. Caspers, Martine C. Morrison, Beatrice Coornaert, Gerard J. P. van Westen, Roeland Hanemaaijer
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2025-06-01
Serija:	Biomedicines
Teme:	liver fibrosis preclinical models fibrosis mechanisms hypoxia
Online dostop:	https://www.mdpi.com/2227-9059/13/6/1448
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