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The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants

Fucosylated glycosaminoglycan (FG) from sea cucumber is a potent anticoagulant by inhibiting intrinsic coagulation tenase (iXase). However, high-molecular-weight FGs can activate platelets and plasma contact system, and induce hypotension in rats, which limits its application. Herein, we found that...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Lisha Lin, Sujuan Li, Na Gao, Weili Wang, Taocui Zhang, Lian Yang, Xingzhi Yang, Dan Luo, Xu Ji, Jinhua Zhao
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-08-01
Schriftenreihe:Marine Drugs
Schlagworte:
fucosylated glycosaminoglycan
anticoagulant
platelet aggregation
contact activation
hypotension
pulmonary embolism
Online-Zugang:https://www.mdpi.com/1660-3397/19/9/487
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