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An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells

Summary: Human induced pluripotent stem cell (hiPSC)-derived intestinal organoids are valuable tools for researching developmental biology and personalized therapies, but their closed topology and relative immature state limit applications. Here, we use organ-on-chip technology to develop a hiPSC-de...

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Principais autores: Renée Moerkens, Joram Mooiweer, Aarón D. Ramírez-Sánchez, Roy Oelen, Lude Franke, Cisca Wijmenga, Robert J. Barrett, Iris H. Jonkers, Sebo Withoff
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2024-07-01
Series:Cell Reports
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Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2211124724005758
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