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CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome

Viruses completely depend on the host translational machinery, but their genomes are often enriched in rare codons and therefore should be translated with poor efficiency. Here, Jungfleisch et al. apply Ribo-Seq and RNASeq to provide a global view on the translational changes occurring during Chikun...

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Autori principali: Jennifer Jungfleisch, René Böttcher, Marc Talló-Parra, Gemma Pérez-Vilaró, Andres Merits, Eva Maria Novoa, Juana Díez
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2022-08-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-022-31835-x
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