Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS

Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure. As motor neuron death occurs late in the disease, therapeutics that prevent the initial disassembly of the neuromuscular j...

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Egile Nagusiak:	Arundhati Sengupta-Ghosh, Sara L. Dominguez, Luke Xie, Kai H. Barck, Zhiyu Jiang, Timothy Earr, Jose Imperio, Lilian Phu, Hanna G. Budayeva, Donald S. Kirkpatrick, Hao Cai, Jeffrey Eastham-Anderson, Hai Ngu, Oded Foreman, Maj Hedehus, Michael Reichelt, Isidro Hotzel, Yonglei Shang, Richard A.D. Carano, Gai Ayalon, Amy Easton
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2019-04-01
Saila:	Neurobiology of Disease
Gaiak:	SOD1 Amyotrophic lateral sclerosis Muscle specific kinase (MuSK) Respiration Diaphragm Neuromuscular junction
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S0969996118303978
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