Distinct maturity and spatial distribution of tertiary lymphoid structures in head and neck squamous cell carcinoma: implications for tumor immunity and clinical outcomes

Abstract The influence of tertiary lymphoid structures (TLSs) on disease progression and the response to immunotherapy in head and neck squamous cell carcinoma (HNSCC) is well established, yet the heterogeneity among these structures remains largely unexplored. We utilized digital spatial profiling...

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Detalhes bibliográficos

Principais autores:	Shuai Xu, Chao Han, Jian Zhou, Di Yang, Hui Dong, Yiwei Zhang, Tingting Zhao, Yi Tian, Yuzhang Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2025-02-01
coleção:	Cancer Immunology, Immunotherapy
Assuntos:	Tertiary lymphoid structures Head and neck squamous cell carcinoma Maturation stage of TLSs Spatial distribution of TLSs TLS scoring system
Acesso em linha:	https://doi.org/10.1007/s00262-025-03952-1
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