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Autophagy is a promising process for linking inflammation and redox homeostasis in Down syndrome

Trisomy 21, characterized by the presence of an additional chromosome 21, leads to a set of clinical features commonly referred to as Down syndrome (DS). The pathological phenotypes observed in DS are caused by a combination of factors, such as mitochondrial dysfunction, neuroinflammation, oxidative...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Xuehai Ma, Weimin Li, Jun Ma, Zhongcheng Han, Shoulong Deng, Sutian Wang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2024-10-01
Schriftenreihe:Frontiers in Pharmacology
Schlagworte:
Down syndrome
autophagy
inflammation
redox homeostasis
stress signalling
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fphar.2024.1491563/full
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