Single-cell transcriptomic analysis identifies downregulated phosphodiesterase 8B as a novel oncogene in IDH-mutant glioma

IntroductionGlioma, a prevalent and deadly brain tumor, is marked by significant cellular heterogeneity and metabolic alterations. However, the comprehensive cell-of-origin and metabolic landscape in high-grade (Glioblastoma Multiforme, WHO grade IV) and low-grade (Oligoastrocytoma, WHO grade II) gl...

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Hlavní autoři:	Zongze He, Yu Peng, Duo Wang, Chen Yang, Chengzhi Zhou, Bo Gong, Siyuan Song, Yi Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-06-01
Edice:	Frontiers in Immunology
Témata:	oligoastrocytoma glioblastoma multiforme cell-of-origin metabolism pathways clinical significance
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1427200/full
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