Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex

Abstract Biological processes are typically actuated by dynamic multi-subunit molecular complexes. However, interactions between subunits, which govern the functions of these complexes, are hard to measure directly. Here, we develop a general approach combining cryo-EM imaging technology and statist...

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Hlavní autoři:	Xu Han, Dongliang Zhang, Lu Hong, Daqi Yu, Zhaolong Wu, Tian Yang, Michael Rust, Yuhai Tu, Qi Ouyang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2023-09-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-023-41575-1
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