Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites

A potential role of berberine, a benzyl isoquinoline alkaloid, in cancer therapy is apparent. Its underlying mechanisms of berberine against breast carcinoma under hypoxia have not been elucidated. We focused on the doubt how berberine restrains breast carcinoma under hypoxia in vitro and in vivo. A...

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Detalhes bibliográficos

Principais autores:	Yanfang Sun, QianQian Zhou, Fangming Chen, Xiaoyan Gao, Linjun Yang, Xiaoyan Jin, Michael Wink, Farukh S. Sharopov, Gautam Sethi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-07-01
coleção:	Pharmacological Research
Assuntos:	Berberine Breast carcinoma Hypoxia-inducible factor-l alpha (HIF-1α) Gut microbiota Plasma endogenous metabolites
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1043661823001731
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