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Caenorhabditis elegans cyclin B3 is required for multiple mitotic processes including alleviation of a spindle checkpoint-dependent block in anaphase chromosome segregation.

The master regulators of the cell cycle are cyclin-dependent kinases (Cdks), which influence the function of a myriad of proteins via phosphorylation. Mitotic Cdk1 is activated by A-type, as well as B1- and B2-type, cyclins. However, the role of a third, conserved cyclin B family member, cyclin B3,...

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Hlavní autoři: Gary M R Deyter, Tokiko Furuta, Yasuhiro Kurasawa, Jill M Schumacher
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2010-11-01
Edice:PLoS Genetics
On-line přístup:http://europepmc.org/articles/PMC2991249?pdf=render
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