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In silico design of the multi-epitope vaccine for lung adenocarcinoma based on hub gene-derived neoantigens

Abstract Background Lung adenocarcinoma (LUAD) is the most prevalent and lethal subtype of non-small cell lung cancer (NSCLC), characterized by an unfavorable 5-year survival rate ranging from 10% to 20%. Neoantigen-based vaccine platforms show encouraging benefits for NSCLC patients. However, the v...

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Huvudupphov: Shaoshuai Li, Minjia Huang, Liqiu Jia, Siyu Liu, Xueting Sun, Daxia Cai, Yanping Su, Minjiang Chen, Chenying Lu, Jiansheng Huang, Jianfei Tu, Jiansong Ji
Materialtyp: Artigo
Språk:Inglês
Utgiven: BMC 2026-03-01
Serie:BMC Cancer
Ämnen:
Neoantigen
Multi-epitope vaccine
Hub gene
Immunoinformatics
Reverse vaccinology
In silico
Länkar:https://doi.org/10.1186/s12885-026-15765-1
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