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Dickkopf1 Up-Regulation Induced by a High Concentration of Dexamethasone Promotes Rat Tendon Stem Cells to Differentiate Into Adipocytes

Background/Aims: Dexamethasone (Dex)-induced spontaneous tendon rupture and decreased self-repair capability is very common in clinical practice. The metaplasia of adipose tissue in the ruptured tendon indicates that Dex may induce tendon stem cells (TSCs) to differentiate into adipocytes, but the m...

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Principais autores: Wan Chen, Hong Tang, Xiangzhou Liu, Mei Zhou, Jiqiang Zhang, Kanglai Tang
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Physiol Biochem Press GmbH & Co KG 2015-11-01
coleção:Cellular Physiology and Biochemistry
Assuntos:
Tendon stem cells
Adipocytes
Dickkopf1
GSK-3β
β-catenin
Dexamethasone
Acesso em linha:http://www.karger.com/Article/FullText/438538
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