Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-<i>b</i>]indol-3-one Derivatives as Potent Inhibitors of EGFR<sup>T790M</sup>/BRAF<sup>V600E</sup> Pathways
Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of anticancer drugs since they are over-activated in several malignancies. We present here the development of a novel series of 5-chloro-indole-2-carboxylate <b>3a–e</b>, <b>4a–c</b> and pyrrolo[3,4-<i>b</i>]indol-3-ones...
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| Principais autores: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI AG
2023-01-01
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| 叢編: | Molecules |
| 主題: | |
| 在線閱讀: | https://www.mdpi.com/1420-3049/28/3/1269 |
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