A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa

Abstract Proteases play a major role in many vital physiological processes. Trypsin-like serine proteases (TLPs), in particular, are paramount in proteolytic cascade systems such as blood coagulation and complement activation. The structural topology of TLPs is highly conserved, with the trypsin fol...

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Detaylı Bibliyografya

Asıl Yazarlar:	Anders B. Sorensen, Per Jr. Greisen, Jesper J. Madsen, Jacob Lund, Gorm Andersen, Pernille G. Wulff-Larsen, Anette A. Pedersen, Prafull S. Gandhi, Michael T. Overgaard, Henrik Østergaard, Ole H. Olsen
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Nature Portfolio 2022-03-01
Seri Bilgileri:	Scientific Reports
Online Erişim:	https://doi.org/10.1038/s41598-022-07620-7
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