Hsa-miR-423-5p selectively loaded in hypoxic exosomes reduces the sensitivity of normoxic hepatocellular carcinoma to sorafenib via autophagy

Abstract Background For patients with advanced hepatocellular carcinoma, sorafenib is considered a highly effective targeted molecular drug; however, sorafenib resistance limits its therapeutic efficacy. Hepatocellular carcinoma, a type of solid tumour, contains hypoxic and oxygen-rich regions withi...

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Bibliographic Details

Main Authors:	Bian Shu, Min Zou, Rui Liao, Diguang Wen, Xianzhi Gao, Jiao Lu, Hua Song, Ziyi Sheng, Zuojin Liu, Yu You
Format:	Artigo
Language:	Inglês
Published:	BMC 2025-11-01
Series:	Cancer Cell International
Subjects:	Hepatocellular carcinoma (HCC) Sorafenib Autophagy Exosomes MiRNA Lipid nanoparticles
Online Access:	https://doi.org/10.1186/s12935-025-04055-8
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