Development and validation of an HILIC/MS/MS method for determination of nusinersen in rabbit plasma
A hydrophilic interaction liquid chromatography tandem mass spectrometry (HILIC/MS/MS) method was developed and validated for the quantitative analysis of the fully phosphorothioate modified oligonucleotide nusinersen. HILIC/MS/MS method is more robust and compatible with mass spectrometry than ion...
Gardado en:
| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2024-05-01
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| Series: | Heliyon |
| Assuntos: | |
| Acceso en liña: | http://www.sciencedirect.com/science/article/pii/S240584402407244X |
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