Synthesis, biological evaluation and clinical trials of Cereblon-based PROTACs
Abstract PROteolysis-Targeting Chimeras (PROTACs) are an emerging class of molecules capable of inducing a forced approximation between a protein of interest (POI) and an E3 ligase enzyme (e.g., Cereblon), leading to the degradation of the POI by the cell’s own machinery. Although in early stages of...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2025-07-01
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| coleção: | Communications Chemistry |
| Acesso em linha: | https://doi.org/10.1038/s42004-025-01598-9 |
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