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Exploratory transcriptomic analysis suggests candidate genes associated with loss of response to ustekinumab in Crohn’s disease

BackgroundDespite the favorable safety and efficacy of ustekinumab in clinical practice for Crohn’s disease, a subset of Crohn’s disease patients still experience loss of response to this treatment. This study was thus conducted to investigate the differential gene expression underlying ustekinumab...

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Principais autores: Jiayi Lin, Tingting Xie, Jiahao Zhong, Yanmei Tu, Chang Xiao, Xueying Huang, Yixi Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-05-01
coleção:Frontiers in Genetics
Assuntos:
Crohn’s disease
loss of response
RNA-seq
transcriptomic
ustekinumab
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fgene.2026.1812181/full
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