The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1α in Vascular Calcification

HIF-1α plays a crucial regulatory role in vascular calcification (VC), primarily influencing the osteogenic differentiation of VSMCs through oxygen-sensing mechanisms. Under hypoxic conditions, the stability of HIF-1α increases, avoiding PHD and VHL protein-mediated degradation, which promotes its a...

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Detalhes bibliográficos

Principais autores:	Zhenghong Zhang, Defan Wang, Renfeng Xu, Xiang Li, Zhengchao Wang, Yang Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-12-01
coleção:	Biomolecules
Assuntos:	hypoxia-inducible factor-1α vascular smooth muscle cell energy metabolism vascular calcification therapeutic target
Acesso em linha:	https://www.mdpi.com/2218-273X/14/12/1592
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