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The euchromatic and heterochromatic landscapes are shaped by antagonizing effects of transcription on H2A.Z deposition.

A role for variant histone H2A.Z in gene expression is now well established but little is known about the mechanisms by which it operates. Using a combination of ChIP-chip, knockdown and expression profiling experiments, we show that upon gene induction, human H2A.Z associates with gene promoters an...

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Autori principali: Sara Hardy, Pierre-Etienne Jacques, Nicolas Gévry, Audrey Forest, Marie-Eve Fortin, Liette Laflamme, Luc Gaudreau, François Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2009-10-01
Serie:PLoS Genetics
Accesso online:http://europepmc.org/articles/PMC2754525?pdf=render
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