Complement pathway dysregulation and astrocyte alterations in Down syndrome: evidence from postmortem brain tissue and iPSC-derived astrocytes

Abstract Background Down syndrome (DS), or trisomy 21 (T21), resulting from an extra copy of chromosome 21, occurs in 1 in 700–1,000 live births. Neuroinflammation is increasingly recognized as a critical contributor to DS neuropathology, although its underlying drivers remain unclear. Methods In th...

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Hauptverfasser:	André Luíz Teles e Silva, Pedro Henrique Prado de Oliveira, Bruno Yukio Yokota-Moreno, Jéssica da Silva Fausto, Jonatan Peña Avila, Helder I. Nakaya, Andréa Laurato Sertié, Bruna Lancia Zampieri
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-12-01
Schriftenreihe:	Acta Neuropathologica Communications
Schlagworte:	Down syndrome Trisomy 21 Complement system Induced pluripotent stem cells Astrocytes
Online-Zugang:	https://doi.org/10.1186/s40478-025-02090-0
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