CD47–SIRPα-targeted therapeutics: status and prospects
CD47 is a “don’t eat me” signal to phagocytes that is overexpressed on many tumor cells as a potential mechanism for immune surveillance evasion. CD47 and its interaction with signal-regulating protein alpha (SIRPα) on phagocytes is therefore a promising cancer target. Therapeutic antibodies and fus...
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| Huvudupphov: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Elsevier
2022-03-01
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| Serie: | Immuno-Oncology and Technology |
| Ämnen: | |
| Länkar: | http://www.sciencedirect.com/science/article/pii/S2590018822000016 |
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