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Camptothecin-PHA nanoparticles attenuate drug-induced gut microbiome dysbiosis and metabolic toxicity

IntroductionThe anticancer drug camptothecin (CPT) has limited clinical applications due to severe toxic reactions.MethodsWe combined CPT with PHBVHHx (PHA) nanoparticles by a modified emulsion method for the first time construct a novel nanomedical drug (CPT-PHA-NPs, CPNs).ResultsIn vitro experimen...

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Autori principali: Shanshuo Liu, Benchen Rao, Wenjie Liu, Xuemei Wang, Haiyu Wang, Liwen Liu, Guizhen Zhang, Junyi Sun, Lei Li, Daixu Wei, Zujiang Yu, Zhigang Ren
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2026-01-01
Serie:Frontiers in Microbiology
Soggetti:
camptothecin
gut microbiome
nanoparticles
PHBVHHx
serum metabolism
Accesso online:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1617468/full
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