Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system

Abstract Silent information regulator 2 (Sir2) proteins typically catalyze NAD+-dependent protein deacetylation. The recently identified bacterial Sir2 domain-containing protein, defense-associated sirtuin 2 (DSR2), recognizes the phage tail tube and depletes NAD+ to abort phage propagation, which i...

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Principais autores:	Jun-Tao Zhang, Xiao-Yu Liu, Zhuolin Li, Xin-Yang Wei, Xin-Yi Song, Ning Cui, Jirui Zhong, Hongchun Li, Ning Jia
格式:	Artigo
語言:	Inglês
出版:	Nature Portfolio 2024-03-01
叢編:	Nature Communications
在線閱讀:	https://doi.org/10.1038/s41467-024-47177-9
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