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Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview

Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced by macrophages and dendritic cells, in response to exogenous or endogenous signals, and drives the differentiation...

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Huvudupphov: Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Materialtyp: Artigo
Språk:Inglês
Utgiven: Frontiers Media S.A. 2021-02-01
Serie:Frontiers in Immunology
Ämnen:
IL-23
IL-17
IL-23/IL-17 axis
inflammatory diseases
autoimmune diseases
Länkar:https://www.frontiersin.org/articles/10.3389/fimmu.2021.637829/full
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