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Centrosomal Protein 55 Regulates Chromosomal Instability in Cancer Cells by Controlling Microtubule Dynamics

Centrosomal Protein 55 (CEP55) exhibits various oncogenic activities; it regulates the PI3K-Akt-pathway, midbody abscission, and chromosomal instability (CIN) in cancer cells. Here, we analyzed the mechanism of how CEP55 controls CIN in ovarian and breast cancer (OvCa) cells. Down-regulation of CEP5...

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Principais autores: Stefanie Muhs, Themistoklis Paraschiakos, Paula Schäfer, Simon A. Joosse, Sabine Windhorst
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2024-08-01
Series:Cells
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Acceso en liña:https://www.mdpi.com/2073-4409/13/16/1382
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