Effect of <i>N</i>-Terminal Peptide Modifications on In Vitro and In Vivo Properties of ¹⁷⁷Lu-Labeled Peptide Analogs Targeting CCK2R

The therapeutic potential of minigastrin (MG) analogs for the treatment of cholecystokinin-2 receptor (CCK2R)-expressing cancers is limited by poor in vivo stability or unfavorable accumulation in non-target tissues. Increased stability against metabolic degradation was achieved by modifying the C-t...

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Detalhes bibliográficos

Principais autores:	Anton Amadeus Hörmann, Maximilian Klingler, Christine Rangger, Christian Mair, Lieke Joosten, Gerben M. Franssen, Peter Laverman, Elisabeth von Guggenberg
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-02-01
Colecção:	Pharmaceutics
Assuntos:	cholecystokinin-2 receptor gastrin peptide receptor radionuclide therapy lutetium-177 theranostics
Acesso em linha:	https://www.mdpi.com/1999-4923/15/3/796
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