Integrating BMSC-inlaid GelMA hydrogels and melatonin-loaded PLGA microspheres into silk fibroin/nanohydroxyapatite scaffolds to repair osteoporotic bone defects

Abstract Background Bone defects are commonly accompanied by disuse-induced osteoporosis, which in turn exacerbates the difficulty of bone regeneration. Biomimetic bone scaffolds represent one of the most promising strategies for bone defect repair. Methods In this study, we constructed poly(lactic-...

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Bibliografische Detailangaben

Hauptverfasser:	Jianwei Lv, Ben Ma, Jianan Li, Zengliang Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-01-01
Schriftenreihe:	Journal of Orthopaedic Surgery and Research
Schlagworte:	Bone defect Disuse osteoporosis Melatonin Methacrylated gelatine Bone mesenchymal stem cells PLGA
Online-Zugang:	https://doi.org/10.1186/s13018-025-06590-6
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