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Protein dynamics and conformational selection in bidirectional signal transduction

<p>Abstract</p> <p>Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational dynamics of EphA4 and its s...

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Bibliografische Detailangaben
Hauptverfasser: Nussinov Ruth, Ma Buyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2012-01-01
Schriftenreihe:BMC Biology
Online-Zugang:http://www.biomedcentral.com/1741-7007/10/2
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