Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models

Abstract Pulmonary fibrosis (PF) is a progressive disease histologically defined by pathological fibroblasts and epithelial cells. PF lungs contain alveolar type 2 epithelial cells (AT2s) that acquire an aberrant intermediate state phenotype. However, the direct role of these cells in PF and the sig...

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Detalhes bibliográficos

Principais autores:	Evan T. Hoffman, Anit Shah, Willy Roque Barboza, Luis R. Rodriguez, Rachna Dherwani, Porter E. Dooley, Kasey Minakin, Yaniv Tomer, Lauren J. Ayers, Dakota Jones, Aditi Murthy, Adam Bennett, Ana N. Lange, Pushpinder S. Bawa, Feiya Wang, Apoorva Babu, Katrina Chavez, Reilly S. Nakamoto, Charlotte H. Cooper, Maria C. Basil, Micha Sam Brickman Raredon, Darrell N. Kotton, Konstantinos-Dionysios Alysandratos, Jeremy Katzen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-09-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-63735-1
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