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Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity

Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet the underlying biology remains unclear. We show that the anti-aging effects of rapamycin and reduced intestinal insulin/insulin growth factor (IGF) signaling (IIS) require the Drosophila FoxA transcription fa...

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Principais autores: Ekin Bolukbasi, Mobina Khericha, Jennifer C. Regan, Dobril K. Ivanov, Jennifer Adcott, Miranda C. Dyson, Tobias Nespital, Janet M. Thornton, Nazif Alic, Linda Partridge
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017-10-01
Serier:Cell Reports
Fag:
longevity
insulin
enterocytes
lifespan
midgut
Drosophila
absorption
FOXA
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124717313177
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