IL-7 producing immunotherapy improves ex vivo T cell functions of immunosenescent patients, especially post hip fracture

Following acute stress such as trauma or sepsis, most of critically ill elderly patients become immunosuppressed and susceptible to secondary infections and enhanced mortality. We have developed a virus-based immunotherapy encoding human interleukin-7 (hIL-7) aiming at restoring both innate an adapt...

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Главные авторы:	Chrystel Marton, Alix Minaud, Charles-Antoine Coupet, Manon Chauvin, Jamila Dhiab, Hélène Vallet, Jacques Boddaert, Nadine Kehrer, Bérangère Bastien, Geneviève Inchauspe, Luc Barraud, Delphine Sauce
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis Group 2023-08-01
Серии:	Human Vaccines & Immunotherapeutics
Предметы:	immunosenescence hip fracture immunotherapy virotherapy interleukin-7 t-cell functions trauma immunosuppression cytokine
Online-ссылка:	http://dx.doi.org/10.1080/21645515.2023.2232247
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