Enhanced MiRISC expression noise reduction by self-feedback regulation of mRNA degradation

The microRNA (miRNA) induced silencing complex (miRISC) is the targeting apparatus and arguably the rate-limiting step of the miRNA-mediated regulatory subsystem – a major noise reducing, though metabolically costly, mechanism. Recently, we reported that miRISC channels miRNA-mediated regulatory act...

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Autores principales:	Shuangmei Tian, Ziyu Zhao, Meharie G. Kassie, Fangyuan Zhang, Beibei Ren, Degeng Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-01-01
Colección:	Computational and Structural Biotechnology Journal
Materias:	MicroRNA (miRNA) MicroRNA induced silencing complex (miRISC) Self-feedback loop Gene expression noise MRNA degradation
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2001037025005604
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