The alternative complement pathway drives neuroinflammation and neurodegeneration in mouse models of glaucoma and optic nerve injury

Glaucoma is a leading cause of irreversible blindness worldwide, characterized by progressive retinal ganglion cell (RGC) loss and optic nerve degeneration. Although elevated intraocular pressure (IOP) is a major risk factor, disease progression can occur despite normal IOP, highlighting the need fo...

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Hlavní autoři:	Cindy Hoppe, Ryo Mukai, Nasrin Refaian, Margarete Karg, Shintaro Shirahama, Maleeka Shrestha, Yinjie Guo, Amarachi Nwogu, Drenushe Krasniqi-Vanmeter, Volha V. Malechka, Bruce R. Ksander, Kip Connor, Meredith Gregory-Ksander
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-11-01
Edice:	Neurobiology of Disease
Témata:	Glaucoma Complement system Neuroprotection Microglia Inflammation
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0969996125003365
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